https://www.ceesdekker.net Secrets
‘Sure, that may be about correct. I seek for a physical comprehension of biological techniques inside of a bottom-up way. I believe you could possibly distinguish three lines of investigation in my team in the meanwhile. The first issues chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in this type of microscopic mobile? We've designed visualisation approaches that allow us to study how, one example is, SMC proteins loop DNA (online video on Youtube) in order to Construct up chromosomes.This question is for tests if you're a human visitor and to stop automated spam submissions.
‘It was only a make a difference of selecting up a book on cell biology and beginning to go through. I had come from a environment of extremely-significant vacuums, cryostats and quantum phenomena, and now I was Performing at place temperature with molecular biology kits.
Sculpting nano-electrodes with a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st at any time examine in the dynamics DNA supercoils and the discovery of supercoil hopping
The coiled-coil from the human Rad50 DNA restore protein includes certain segments of improved versatility
Size Charge of specific carbon nanotubes by nanostructuring Together with the scanning tunneling microscope
Illustration (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in pink, as well as a 3D rendering of your motion with the DNA rod is displayed.
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one). The existing–voltage curves https://www.ceesdekker.net showed significant modulations with gate voltage, even at space temperature, which was consistent with band bending in a very ~0.6 eV bandgap semiconducting nanotube. These details also confirmed which the conductance could possibly be modulated by six orders of magnitude by altering the gate voltage. The outcome of the get the job done — a home-temperature transistor produced from a single carbon nanotube molecule — have been posted in Character in Might 1998.
Due to the fact 2000 he moved to single-molecule biophysics and nanobiology, with investigation from studies of DNA loop extrusion and supercoiling to DNA translocation by nanopores. More just lately his investigate has focused on finding out chromatin composition and mobile division with germs on chip, when he is also trying to in the long run Establish synthetic cells from the bottom up.
Cees Dekker is Distinguished University Professor at TU Delft. Educated as a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes during the nineties. Given that 2000, he moved to single-molecule biophysics and nanobiology. His latest investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome composition, specifically SMC motor protein; and (iii) building a dwelling synthetic mobile from lifeless molecules. Dekker is undoubtedly an elected member in the KNAW and fellow to the APS as well as IOP.
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim in the pore is highlighted in pink, along with a 3D rendering with the movement in the DNA rod is shown.